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What is a birth injury?

A birth injury is an injury that happens to a baby during the birthing process. The majority of birth injuries are minor and will heal on their own within the first few weeks after delivery. For example, minor birth injuries include the bruising, swelling and minor nerve damage that may occur as the baby moves through the birth canal.

Other birth injuries, however, are more severe and may cause long-term damage to the child. For example, if the baby is deprived of oxygen for even a short period of time, the child could develop cerebral palsy. Cerebral palsy is a condition that occurs when there has been trauma to the brain, affecting the development of the child’s ability to control and coordinate movement. Cerebral palsy can cause seizures, vision and hearing problems and mental retardation. It is estimated that 5% of cerebral palsy cases are linked to birth injuries.
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Erb’s palsy is another serious condition that can occur as a birth injury. Erb’s palsy occurs when the nerves in the neck and shoulder are stretched or torn, resulting in weakness or paralysis in the arm. The nerves can be stretched during a difficult delivery, either through the natural birth process or if the physician has to use force to deliver the baby. In the majority of cases, the effects will be temporary. But in cases where the nerves were torn, the damage can be long-term or even permanent and may require surgical repair.
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At least six per cent of pregnant women in Quebec take prescription medications that are known to harm the fetus, raising questions about the medical judgment of some of their physicians, especially general practitioners, suggests a new study by Université de Montréal researchers. BUY ACCUTANE ONLINE

To the surprise of the researchers, they found that one of the medications, the anti-acne drug Accutane, is still available on the market without a «proper risk-management program.»

The researchers also concluded that some drugs are being over-prescribed, especially benzodiazepine, used in the treatment of anxiety. This class of drugs has been linked to breathing problems and withdrawal symptoms in newborns.

«Clearly, the physician has a responsibility to warn pregnant patients about the risks of congenital malformations associated with certain drugs,» said lead researcher Anick Bérard, a professor at the U de M’s faculty of pharmacy.

More than two decades after Accutane was approved for the treatment of severe acne, the researchers discovered that 71 pregnant women took it from 1998 to 2002 – the period under study. Physicians have long known that the drug increases by 10 times the risk of a congenital malformation.

Bérard conceded that some young women might be sharing the drug without the knowledge of their physician, but she urged doctors to be more rigorous and careful in prescribing medications to pregnant women. The study noted that 73 per cent of the prescriptions were written by GPs.

In contrast, obstetrician-gynecologists tend to take a more prudent approach. The Society of Obstetricians and Gynaecologists of Canada regularly informs its members about the risks of some prescription medications. For example, in a November 2007 article on statins, the society warned that «statins should be avoided during pregnancy, and pregnant women exposed to cholesterol-lowering drugs should be monitored closely.»

The researchers examined the medical records of 109,344 women gleaned from the Quebec Pregnancy Registry.

They found that 56 per cent of the women filled at least one prescription for any medication during pregnancy. Of the total number of women, 6.3 per cent took at least one drug with recognized embryo-toxic or feto-toxic effects.

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Accutane (Isotretinoin) and Other Retinoids

•             What is Accutane?

•             Who should not take isotretinoin?

•             What birth defects are caused by use of isotretinoin during pregnancy

•             What is nodular acne?

•             What is iPLEDGE?

•             What should a woman of childbearing age do before taking isotretinoin?

•             What does iPLEDGE require for women who can become pregnant?

•             Is it safe to breastfeed while taking isotretinoin?

•             What other precautions should a woman take during treatment with isotretinoin?

•             What are other iPLEDGE requirements?

•             Are there safer acne medications for women of childbearing age?

•             Are topical retinoids safe in pregnancy?

•             Are there other retinoids that are unsafe during pregnancy?

•             Can high doses of vitamin A cause birth defects?

•             What is the role of the March of Dimes in the study of retinoids?

•             References

What is Accutane?

Accutane (isotretinoin) is a prescription medication used to treat a severe form of acne (nodular or “cystic” acne) that has not been helped by other treatments, including oral antibiotics. Other brands of isotretinoin (Amnesteem, Claravis, Sotret) also are available.

Isotretinoin is a member of a family of drugs called retinoids, which are related to vitamin A. When taken during pregnancy, isotretinoin and other retinoids can cause miscarriage or very serious birth defects.

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Who should not take isotretinoin?

Women who are pregnant, planning pregnancy, having sex without birth control or breastfeeding should not take isotretinoin.

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What birth defects are caused by use of isotretinoin during pregnancy?

There is an extremely high risk of birth defects if a woman takes isotretinoin during pregnancy, even if she takes a small amount of the drug for a short period. Birth defects caused by isotretinoin include (1):

•             Hydrocephaly (enlargement of the fluid-filled spaces in the brain)

•             Microcephaly (small head and brain)

•             Mental retardation

•             Ear and eye abnormalities

•             Cleft palate and other facial abnormalities

•             Heart defects

Isotretinoin can cause birth defects in the early weeks after conception when a woman often does not know she is pregnant. Even babies without obvious birth defects may have mental retardation or learning disabilities (1, 2). The drug also increases the risk of premature delivery and infant death (1, 2).

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What is nodular acne?

Nodular acne causes many red, swollen lumps in the skin and can leave permanent scars. This form of acne sometimes does not respond to treatments other than isotretinoin. The drug clears the skin of most affected individuals for prolonged periods.

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What is iPLEDGE?

All patients, including men, who take isotretinoin must participate in a risk-management program called iPLEDGE. The Food and Drug Administration (FDA) started this program in 2005 with two goals (3):

•             Ensuring that no pregnant woman starts taking isotretinoin

•             Ensuring that no woman taking isotretinoin becomes pregnant

The FDA approved the first form of the drug, Accutane, in 1982. Before it was approved, testing had shown that the drug could cause birth defects in animals. The manufacturer of Accutane, Roche Pharmaceuticals (a division of Hoffmann-La Roche, Inc.), warned against its use by pregnant women, but pregnancies resulting in birth defects still occurred.

Subsequently, the FDA and the manufacturers of all brands of isotretinoin implemented voluntary risk-management plans to prevent pregnant women from using the drug. These programs were not successful in preventing drug exposure during pregnancy. As a result, the FDA started iPLEDGE, a stronger, mandatory risk-management program.

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What should a woman of childbearing age do before taking isotretinoin?

A woman should discuss with a doctor who is experienced in isotretinoin treatment whether the drug is right for her. Besides causing birth defects, isotretinoin can cause serious side effects for the woman, possibly including mental health problems (2, 3). In many cases, safer treatments (see below) may work to clear up acne.

If a woman decides to take isotretinoin, she must follow the steps required by iPLEDGE.

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What does iPLEDGE require for women who can become pregnant?

iPLEDGE requires that women follow these steps before, during and after isotretinoin treatment:

Before treatment (3):

•             Have two negative pregnancy tests, including one right before starting the drug

•             Sign a patient information/consent form containing warnings about the risk of birth defects if the fetus is exposed to isotretinoin

•             Agree to use two effective forms of birth control, which must be used at the same time (unless abstinence is the chosen method), for at least one month before and throughout treatment with the drug and for one month after stopping the drug

•             Register with iPLEDGE by phone (866-495-0654) or on the Internet, and agree to follow all instructions in the iPLEDGE program

During treatment:

Each month a woman receives a 30-day supply of isotretinoin. To refill her prescription, she must:

•             Have a negative pregnancy test

•             Enter her two types of birth control into the iPLEDGE system (by phone or Internet)

•             Answer questions about the iPLEDGE program and preventing pregnancy (by phone or Internet)

After treatment:

•             Have a pregnancy test after her last dose

•             Continue to use two forms of birth control for one month

•             Have another pregnancy test one month after her last dose

If a woman taking isotretinoin does become pregnant, she should stop taking the drug and call her health care provider. She or her provider must report the pregnancy to the FDA at (800) FDA-1088 and to iPLEDGE (3). Reporting allows the FDA and the drug companies who make isotretinoin to monitor the success of the iPLEDGE program and to make any necessary changes to prevent pregnancy exposures.

A woman should never attempt to get isotretinoin over the Internet because she will miss out on important safeguards to protect her health. The FDA provides more information about the dangers of buying isotretinoin on its Web site.

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Is it safe to breastfeed while taking isotretinoin?

Women should not breastfeed while using isotretinoin and for one month after stopping the drug because it is not known whether it could harm the baby (2, 3).

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What other precautions should a woman take during treatment with isotretinoin?

Most women are treated with isotretinoin for about 15 to 20 weeks (3). During this time, a woman should check with her provider before taking any other medications. A woman should avoid certain medications while she is taking isotretinoin (2, 3):

•             St. John’s wort: This herbal preparation may cause birth control pills to work less effectively and put a woman at increased risk of pregnancy.

•             Tetracycline: This antibiotic can increase the risk of serious side effects when taken with isotretinoin.

•             Dilantin (phenytoin): This anti-seizure medication, when taken with isotretinoin, can weaken bones.

•             Corticosteroids: When taken with isotretinoin, these medicines (used to treat arthritis, severe asthma and a number of other conditions) can weaken bones.

•             Progestin-only birth control pills: When taken with isotretinoin, this form of birth control may not be effective.

•             Vitamin A supplements: These vitamins are related to isotretinoin and can include the risk of serious side effects.

Women or men who use isotretinoin should not give blood while taking the drug and for one month afterward, because the drug might cause birth defects if a pregnant women receives the blood (2, 3). Individuals should never share their prescription for isotretinoin with anyone else.

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What are other iPLEDGE requirements?

All doctors who prescribe the drug and pharmacists who sell it also must register with iPLEDGE (4). Each must agree to certain responsibilities for preventing pregnant women from taking the drug. For example:

•             Doctors are responsible for counseling women about birth control and the risks of isotretinoin, explaining the iPLEDGE program, and documenting in iPLEDGE a negative pregnancy test for women taking the drug each month.

•             Pharmacists can fill a prescription only after receiving authorization from iPLEDGE.

These requirements should help ensure that each woman has had an appropriately timed negative pregnancy test before starting the drug and each month before she refills her prescription. The requirements also should help ensure that all women of childbearing age receive continuing counseling about the safety precautions necessary to prevent fetal exposure to the drug.

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Are there safer acne medications for women of childbearing age?

Most women with acne do not have severe nodular acne. Their skin problems often respond to safe topical (applied to the skin) or oral medications. Topical preparations of the antibiotics erythromycin or clindamycin are safe choices even during pregnancy, as is benzoyl peroxide, an antibacterial agent that also dries the skin (5).

If topical preparations do not clear the skin, a woman’s provider may recommend oral treatment with antibiotics, such as erythromycin, which has not been associated with birth defects. If she is not planning pregnancy, treatment with oral contraceptives (which should not be used during pregnancy) also may be effective (5).

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Are topical retinoids safe in pregnancy?

Topical retinoids are used to treat acne and sun-damaged skin. These include topical tretinoin (Retin A, Renova), adapalene (Differin) and tazarotene (Tazorac). Small amounts of these drugs may be absorbed through the skin into the bloodstream.

Studies suggest that topical retinoids do not cause birth defects (6). However, some questions about their safety remain, due to a few reports of birth defects in babies of women who used these preparations during pregnancy (6). Until more is known about the safety of topical retinoids during pregnancy, it’s best for women who are pregnant or planning pregnancy to avoid them.

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Are there other retinoids that are unsafe during pregnancy?

All oral retinoids pose a risk of birth defects similar to those caused by isotretinoin and should be avoided during pregnancy. As with isotretinoin, women should have a pregnancy test before starting these drugs and another each month. Women also should use two reliable forms of birth control during treatment and for varying periods of time after discontinuing use of these drugs.

•             Soriatane (acitretin): This retinoid is used to treat severe psoriasis, a chronic disfiguring skin disease. Soriatane can remain in the body for an extended period. It should not be used by any woman who plans to become pregnant within three years after stopping the drug (7). Women should continue to use two reliable forms of contraception for at least three years after stopping the drug (7). Women should not drink alcohol while taking the drug or for two months afterward (7). This combination causes the body to turn Soriatane into etretinate (the active ingredient in Tegison), which may remain in the body for many years after treatment ends.

•             Tegison (etretinate): This psoriasis medicine has been replaced by Soriatane and is no longer sold in the United States. Tegison stays in the body for a prolonged period. Any woman who has used Tegison should discuss with her doctor if and when it may be safe for her to attempt pregnancy.

•             Vesanoid (tretinoin): This drug is used to treat a blood cancer called acute promyelocytic leukemia. Women should continue to use two forms of contraception for one month after stopping treatment (8).

•             Targretin (bexarotene): This retinoid is used to treat a form of blood cancer called T-cell lymphoma. A woman should continue using two reliable forms of contraception for one month after stopping the drug (9).

A number of new retinoids are being tested for their effectiveness in treating and, in some cases, preventing various forms of cancer, including breast, ovarian and lung cancer. These drugs appear to cause cancer cells to behave like normal cells, possibly leading to remission of some cancers. If these drugs prove successful, women and their doctors should pay careful attention to the risks for birth defects associated with use of these drugs.

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Can high doses of vitamin A cause birth defects?

Vitamin A is crucial for normal fetal growth and development. However, too much of it may cause birth defects. A 1995 study found that women who took more than 10,000 IUs (international units) of vitamin A daily in the first two months of pregnancy doubled their risk of having a baby with birth defects (10). The birth defects were similar to those seen in isotretinoin-exposed babies.

The FDA’s current daily value (DV) for vitamin A is 5,000 IUs (11). Other studies have suggested that doses less than 25,000 IU probably do not cause birth defects, but the lowest dose that can cause birth defects is unknown (6).

The body makes its own vitamin A, when needed, from vitamin A precursors, such as beta carotene, which is found in yellow and green vegetables and some multivitamins. This form of the vitamin is believed to be completely safe during pregnancy.

However, much of the vitamin A we consume is the preformed vitamin which, in excessive amounts, can cause birth defects. Preformed vitamin A is found in many vitamin supplements and some foods, including meats (especially liver), eggs, dairy products and fortified breakfast cereals.

A pregnant woman should be sure that her multivitamin or prenatal supplement contains no more than 5,000 IUs of preformed vitamin A, and she should not take any vitamin A supplements beyond that amount. She also should limit the amount of liver she eats.

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What is the role of the March of Dimes in the study of retinoids?

The March of Dimes has supported research on isotretinoin and was instrumental in bringing to public attention the need for more stringent guidelines concerning its use. The March of Dimes continues to support research on the role of retinoids in both normal and abnormal fetal development, in order to better understand how these drugs may cause birth defects, with the ultimate goal of learning how to prevent them.

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References

1.            iPLEDGE. About Isotretinoin: Contraindications and Warnings. Accessed 2/12/08.

2.            Food and Drug Administration (FDA). Patient Information Sheet: Isotretinoin (Marketed as Accutane). Accessed 2/11/08.

3.            iPLEDGE. The iPLEDGE Program Patient Introductory Brochure, effective 12/2/07.

4.            Food and Drug Administration (FDA). FDA Alert for Healthcare Professionals: Isotretinoin (Marketed as Accutane), accessed 2/11/08.

5.            Deitch, H.R., and Hillard, P.J.A. A Gynecologist’s Guide to Acne. Contemporary Ob/Gyn, January 2002, pages 88-93.

6.            Reproductive Toxicology Center (ReproTox). Tretinoin, Adapalene, Tazarotene, Vitamin A, accessed 2/11/08.

7.            Stiefel Laboratories. About Soriatane: Important Safety Information for Females. Accessed 2/12/08.

8.            Roche U.S. Pharmaceuticals. Complete Product Information: Vesanoid (Tretinoin) Capsules, accessed 2/12/08.

9.            Eisai, Inc. Targretin (Bexarotene) Capsules: Patient’s Instructions for Use. Accessed 2/12/08.

10.          Rothman, K.J., et al. Teratogenicity of High Doses of Vitamin A Intake. The New England Journal of Medicine, volume 333, number 21, November 23, 1995, pages 1365-1373.

11.          NIH Office of Dietary Supplements. Dietary Supplement Fact Sheet: Vitamin A and Carotenoids. Updated 4/23/06.

March 2008

http://www.marchofdimes.com/professionals/14332_1168.asp

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What causes acne?

Human skin has two necessary qualities. It is flexible and offers a waterproof protection to the rest of the body. Both these qualities are produced by a system of sebaceous glands which release an oil into the skin. These glands are sited next to the pores and follicles which produce body hair. When all is working well, the body produces just the right amount of oil. But, if anything disturbs the balance of hormones, too much oil may fill up the pores and trap the dead flakes of skin that would otherwise fall off. When this happens, a warm environment, much loved by a skin bacterium opens for business. The bacterium suddenly goes into overdrive replication and triggers an infection. The first you know of this is an emerging spot.

Who is most often affected?

At one time or another during puberty, it affects more than 80% of all teenagers but the majority «grow out of it». Only a relatively small percentage suffers the condition into adulthood. It is rare for the problem to affect people over the age of forty. The hormone most associated with acne is androgen and, despite the fact this is predominantly a male sex hormone, acne is five times more common among adult women than men. The reason for this is an imbalance caused by menstruation and pregnancy. In some women, the trigger is the use of one of the oral contraceptives.

How does accutane work?

It has two slightly different effects. The first is a reduction in the amount of oil produced by the sebaceous glands. The second is to make the oil less retentive so that more dead skin falls from the healthy skin. The combined result is that there are fewer welcoming warm pores for the bacterium to enjoy.

What is the build up to the use of accutane?

The first stage is to use creams and lotions like benzoyl peroxide. The theory is that keeping the surface of the skin clear of dead cells helps to prevent the formation of the right environment for the bacterium to start growing fast. If that fails, the second stage is the use of antibiotics to reduce the resulting infections in the pores and follicles. If these fail, whether on their own or in combination, dermatologists will usually confirm the use of accutane.

Why is the use of accutane limited?

There are no problems in the use of accutane by teenage boys and adult men. But there is a clear risk that the use of accutane during pregnancy will damage the fetus. A high percentage of babies are born with defects. Since acne is five times more common among women of child-bearing age, the use of accutane has to be tightly controlled.

What are the myths about acne…

…and how does the iPLEDGE program work? To help protect women when using accutane, the iPLEDGE program insists on provable contraceptive measures.

There is much cruelty in the world and, particularly among children and young adults, unkind words can seriously damage self-esteem. Acne is a rite of passage, a period of unhappiness most have to endure as part of the price of becoming an adult. It is not a disease but that does not prevent people from being seriously injured. This has produced a medical challenge. What can people do to reduce this public display of difference? There are a number of myths offering worthless advice:

Washing often clears the skin

In fact, the reverse is true. If you use any kind of abrasive cloth or product in the hope this will solve the problem, you are more likely to damage you skin and make the acne worse.

The sun will clear skin blemishes

Again this is dangerous. So-called sun burn is damage to the surface of the skin which can cause irritation and make the acne worse.

Reduce stress to keep acne away

Ironically, some drugs used to combat anxiety cause acne as a side effect. There is no provable link between stress and acne except that cruel people cause stress to those with acne

Avoid sex to avoid acne

This is the abstinence brigade producing another reason to encourage teenagers to avoid sex including masturbation. While there may be a link between androgen levels and the libido of young men, there is no scientific evidence that the absence of sexual activity has any effect on acne.

Acne is caused by what we eat

Again, there is no scientific evidence of any link between particular foods and acne.

What is the iPLEDGE program?

Because of the risk to all girls and women capable of conceiving a child, the iPLEDGE system requires those who want access to accutane to pledge they will take practical contraceptive measures to prevent pregnancy. The doctor, usually a specialist dermatologist, will ask the girl or woman to pick two different methods of contraception and to use them for at least thirty days. Assuming that one of the methods is an oral contraceptive, the woman will then be tested to ensure that she is actually incapable of contraception. If this proves the case, the accutane will be prescribed. The use of contraceptive measures must be continued during the period of treatment, and for at least thirty days after the course of treatment is completed. There must be no chance of a pregnancy.

Because some women have a religious objection to all forms of contraception, they buy their accutane through online pharmacies without the need for a prescription. This is, of course, perfectly safe, so long as no pregnancy occurs during the period of treatment.

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Accutane (isotretionoin) is prescribed for patients suffering from severe forms of nodular acne that did not respond well to other ways of treatment. Taking Accutane € during pregnancy is fraught with severe birth defects in the baby, which is why every woman of a child-bearing potential must sign a special iPLEDGE agreement where she promises to use at least two reliable methods of birth control. Being allergic to the active ingredient of this medicine (isotretinoin) is a direct contraindication. You will probably not be able to take Accutane and your health care provider will recommend you an alternative. In addition to some other side effects this medicine can affect your vision at night. This side effect usually occurs suddenly at any point of the treatment, so you should be careful when operating machinery or driving a car at this time of the day.

Accutane

Accutane (isotretionoin) is a medicine available by prescription used to treat severe nodular acne that could not be improved using other methods of treatment. Every woman of a child-bearing potential is supposed to sign a special iPLEDGE agreement, according to which she will be using two different methods of birth control throughout the entire period of treatment to avoid getting pregnant. Accutane has been reported to cause severe birth defects, so you should use two different methods of birth control that you have to previously discuss with your health care provider. Taking hormonal contraceptives is one of the ways you can go – just make sure you are not taking any other supplements of drugs. Hormonal contraceptives, however, such as birth control pills, implants, injections, intrauterine devices etc can become less efficient if you are taking certain medications, vitamins and herbal supplements. If you experience discomfort when wearing the contact lenses you should know that this is a normal side effect of taking Accutane. If you think you may have become pregnant while taking Accutane, stop taking this medicine and consult your health care provider right away to learn about which options you have. Report to your doctor any medicines you are taking at the moment to avoid drug interference. Let your doctor know if you are taking oral steroids, tetracycline antibiotics, seizure medications, vitamin A or any other ones that you think may cause unpleasant symptoms to happen if combined with Accutane.

Essential information about accutane

Everything in life is a trade-off between the hoped-for benefits and the feared costs. There are risks in most of the things you do from driving a car to skiing down a mountain. This is particularly true in medicine. Only a few of the top-selling drugs are free from serious side effects. The FDA reviews the scientific evidence from clinical trials and makes a decision that the majority can use each approved drug safely. The definition of «the majority» is important. Usually, the percentage at risk is less than 2%. In some cases, however, there is a greater certainty of the number at risk.

«Buy Accutane« ® is a highly effective treatment for acne. It works when the other medications have failed. For young and adult men, there is no problem in its use. Almost all will find their skin is cleared after one course of treatment. If a second course of treatment is required, this is almost always successful. Acne is not a disease. It does not cause serious physical injury although there can be residual scarring. The problem lies the destructive cruelty of young people who seem to delight in humiliating those affected. Emotional damage can run deep with self-confidence completely destroyed. As puberty advances towards adulthood, the gender ratio of those affected shifts to 5:1. Five times as many women are affected. Unfortunately, there is clear evidence that women who use accutane during pregnancy give birth to physically damaged babies. Despite this, the FDA has continued to allow accutane to be sold.

The FDA has introduced the iPLEDGE scheme for all women of child-bearing age who wish to use accutane. Before they can begin treatment, they have to begin using two different forms of contraception. This must run for 30 days before the drug is started and continue for a further 30 days after the drug treatment has ended. There must be no possibility that a pregnancy can occur while accutane is in the body. This creates some difficulties because many women have a religious objection to the use of any form of contraception. In such cases, treatment through the conventional medical service is denied because women are tested for the presence of oral contraceptive in their blood before a prescription is written for the drug. The choice for young women therefore comes down to living through the social problems with acne or buying the drug through online pharmacies and hoping that pregnancy can be avoided.

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Рубрика: Accutane — admin @ 4:22 дп

What is Accutane and how does it work?

Accutane (also known as Isotretinoin), or Roaccutane as is also known in parts of the world, was discovered in 1979 when it was first given to patients with severe acne, most of whom reacted with dramatic and permanent clearing of their acne symptoms. It is a vitamin A derivative (13-cis-retinoic acid) which is administered orally in pill form, normally for 15-20 weeks (3.5-4.5 months). It was originally prescribed for people with severe acne that did not respond to other treatments, but has gained in popularity in the past 25 years and is prescribed more and more frequently for less severe acne. This practice is controversial because Accutane is a serious medication and causes side effects which can be as devastating as they are widespread.

Exactly how Accutane works on a cellular level is unknown, but we do know that it affects all of the four ways that acne develops.

  1. It dramatically reduces the size of the skin’s oil glands (35%-58%) and even more dramatically reduces the amount of oil the skin produces (around 80%).
  2. Acne bacteria (P. acnes) live in skin oil. Since oil is so dramatically reduced, so is the amount of acne bacteria in the skin.
  3. It also slows down how fast the skin produces skin cells inside the pore, which helps pores from becoming clogged in the first place.
  4. It has anti-inflammatory properties.

Although acne may get worse within the first month of Accutane use, the ultimate results are usually dramatic. Accutane works to achieve partial or complete clearance of acne in about 95% of people who complete a cycle, regardless of whether they have inflammatory or non-inflammatory acne. The majority of people who take it see their acne effectively cured, experiencing long-term remission of acne symptoms. Studies show an average relapse rate of 25%, and in these cases sometimes a second course is given. This relapse rate is dose-dependent. Patients who receive a cumulative dose of 100-120mg/kg see the best results and lowest relapse rates. Patients who receive a lower dose relapse more frequently. Daily dosage depends on how much the patient weighs;0.5mg – 2mg/kg is typical.

Accutane need not be paired with other medications. For people who have problems handling Accutane, intermittent dosage is potentially an option and is being studied for effectiveness. Generic forms of Accutane may or may not be as therapeutic or safe. This is based on only one study which was performed in the UK in 2006. Out of the 14 generic brands studied, 13 failed to match Roaccutane (as it is called in the UK) in one or more tests and 11 failed in three or more tests. More studies like this one are needed to obtain better data on this subject.

17.11.2009

Accutane!

Рубрика: Accutane — admin @ 12:00 пп

What is Accutane?

Accutane is one of the most powerful prescription drugs, created around the acne fighting ingredient vitamin A. It has many imitators, and it essentially works by stopping all oil production in the skin, which is a commonly blamed cause of acne, in part because it is obvious.

History of Accutane

Accutane has been around for a number of years, and it has been presented and used as the last resort for those who suffer from acne and have found no success with anything else. Dermatologists specifically wait until users have literally tried everything else to even think about recommending Accutane. But for most users, it does provide some kind of results.

Benefits

Accutane completely stops oil production, and it is literally the only treatment that has been shown to work against severe forms of acne outside the major forms of acne such as acne conglobata. It is sometimes also the only acne treatment that works for those suffering from severe acne. However, it does not work for everybody, sometimes actually making acne worse. In fact, our research has revealed that Accutane can cause some severe side effects as well as not being effective against acne in certain cases.

Side Effects

Oil is necessary to the skin to some degree. It is the excess oil that is the problem. But Accutane stops all, causing dryness, discomfort with contacts, joint pain, back pain, dizziness, drowsiness, nervousness, dryness of the lips, mouth, nose, and skin, cracking or peeling of skin, itching, rashes, or changes in finger nails. In extreme cases, it has also been known to cause severe birth defects or even fetal death, depressed moods, trouble concentrating, insomnia, agitation, change in behavior, hallucinations, thoughts of suicide, sudden numbness or weakness on one side of the body, blurred vision, sudden or severe headaches, vomiting, hearing problems, seizures, severe pain in upper stomach, fast heart rate, loss of appetite, dark urine, clay colored stools, jaundice, severe diarrhea, rectal bleeding, black, bloody, or tarry stools, fever, chills, body aches, flu symptoms, purple spots under the skin, easy bruising or bleeding, or bone fracture.

Conclusion

While Accutane is effective for some severe cases of acne, it really only attacks one major cause. It also goes too far to say the least and causes many serious side effects that go beyond the expected dry skin. It should not be used without serious caution and consideration, as some of the side effects can not only be serious, but affect you for the rest of your life. There are various other solutions which are more comprehensive and also come without side effects.

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Рубрика: Accutane — Метки: — admin @ 11:13 дп

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